In 4 visits: at month 0, 6, 12, and 18.

This test will give information about the efficacy and safety of the treatment, based on the levels of ovary hormones, cholesterol, liver and kidney function, electrolytes, red and white blood cells, and markers of cardiovascular risk.

Ideally this test is fast and represents a minimally painful experience.

In 3 visits: at months 0, 12, and 18.

This test will give information about the body’s response to sugar (glucose).

• It requires a first (baseline) blood draw.
• After this, you will drink a sugary drink and then, you will have three more blood draws after 30, 60, and 120 minutes.
• The total amount of blood to be extracted will not exceed 20 ccs, which does not constitute a risk for health.

In 3 visits, at months 0, 12, and 18.

This assessment will give information about the amount and distribution of body fat and the calcium content of the bones. It consists of a whole body X-ray.

• It takes about 10 minutes, does not need previous preparation and is painless.
• The radiation produced is minimal, about 6-10 times less than a chest X-ray.
• You will have to remove any piercing or jewellery.

In 3 visits, at months 0, 12, and 18.

This assessment will give information about the amount and distribution of visceral (within the abdominal cavity), subcutaneous fat (under the skin) and liver fat.

• It takes about 20 minutes and does not need prior preparation.
• You will have to remove any piercing or jewellery.
• You must remain still throughout the imaging process.
• It is painless; however, the MRI machine can be narrow and noisy (you may be given headphones or earplugs).
• No radiation is produced.

In 3 visits, at months 0, 12, and 18.

It is used to measure the thickness of this artery, which may influence cardiovascular risk.

• It takes about 20 minutes and does not need previous preparation.
• It is painless.
• No radiation is produced.