Hormonal health is one of the most powerful—and often overlooked—foundations of wellbeing. Hormones guide essential processes such as growth, metabolism, mood, and fertility. When they fall out of balance, the effects can be profound, especially for girls and women.
Have you ever noticed subtle changes in your energy, mood, or cycle and wondered what your body might be trying to tell you? You’re not alone. It is very usual to experience symptoms can’t be explained, often without realising that hormones could be part of the story. Understanding these signals is the first step toward taking control of your wellbeing.
Hormonal health is the body’s internal communication system. Through tiny chemical messengers called hormones, the endocrine glands coordinate how we grow, how we sleep, how we process energy, and how our reproductive system functions. When this system works well, everything feels “in sync.” But when it becomes disrupted (even slightly) it can affect daily life in ways that range from subtle (fatigue, mood changes) to severe (metabolic problems, reproductive challenges).
For women and adolescent girls, hormonal fluctuations are a normal part of life. However, persistent irregularities can signal underlying conditions that deserve attention and proper medical guidance.
PCOS: a hormonal condition with metabolic roots
Polycystic Ovary Syndrome (PCOS) is one of the most common hormonal and metabolic disorders affecting girls and women. Beyond common symptoms such as irregular cycles, weight gain or acne, PCOS involves deeper imbalances in how the body manages insulin and energy.
This combination of reproductive and metabolic challenges makes PCOS a complex condition with lifelong implications. Early detection and targeted treatment are essential—not just to relieve symptoms today, but to support long-term wellbeing. If you feel you may be noticing signs of PCOS or hormonal imbalance, consider speaking with your healthcare provider. A professional can help you understand what your body is signaling and guide you toward evidence-based options. This may include a combination of healthy lifestyle habits and, when appropriate, medication.
Projects like SPIOMET4HEALTH aim to combine both approaches: a treatment that works at the metabolic and hormonal level, supported by healthy routines that empower patients in their day-to-day lives.
How SPIOMET4HEALTH is pioneering a new approach
SPIOMET4HEALTH investigates the first therapy aiming not only to manage visible PCOS symptoms, but to restore healthier hormonal and metabolic function at its roots. The project combines three medications — spironolactone, pioglitazone and metformin — in a single daily tablet (SPIOMET), together with lifestyle measures. This simplifies treatment and potentially improves adherence, compared to previous approaches where drugs had to be taken separately. The aim is ambitious: normalize ovulation and endocrine-metabolic balance, reduce excess hepato-visceral fat, and ultimately address the root causes of PCOS, rather than merely suppress symptoms.
The project has made substantial progress and now entered a decisive phase: the analysis of clinical trial data. In the coming months, the consortium will examine whether the SPIOMET medication truly normalises ovulation and restores endocrine-metabolic balance more effectively than placebo.
By integrating clinical research, patient involvement, and scientific innovation, SPIOMET4HEALTH is paving the way for more effective female care.